Abstract
According to the 2021 World Drug Report, around 275 million people use drugs of abuse, and 36 million people suffer from addiction, fostering a thriving market for illicit substances. In Italy, 30,083 people were reported to the Judicial Authority for offenses in violation of the Italian Law D.P.R. 309/1990. These offences are sentenced after a qualitative–quantitative analysis of seized materials. Given the large quantity of seized drugs and the need to perform accurate analytical determinations, Italian forensic laboratories struggle to complete analyses in a short time, delaying the entire reporting process needed to achieve sentencing. For this purpose, an UHPLC-MS/MS-based platform was developed at the University of Milano-Bicocca to support law-enforcement authorities. Software was designed to easily manage street seizure acquisition, documentation registration, and sampling. A sensitive UHPLC-MS/MS method was fully validated for the quantification of the traditional illicit substances (cocaine, heroin, 6-MAM, morphine, amphetamine, methamphetamine, MDMA, ketamine, GHB, GBL, LSD, trans-∆9-THC, and THCA) at the ppb level. The final report is relayed to the Prefecture in 3–4 days, even within 24 h for urgent requests. The platform allows for semi-automatic data handling to minimize erroneous results for an accurate report generation by standardized procedures.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference35 articles.
1. (2022, November 26). World Drug Report. Available online: //www.unodc.org/unodc/en/data-and-analysis/wdr2021.html.
2. Analysis of Illicit Drugs Seized in the Province of Florence from 2006 to 2016;Bertol;Forensic Sci. Int.,2018
3. European Monitoring Centre for Drugs and Drug Addiction (2021). European Drug Report 2021: Trends and Developments, Publications Office.
4. (2022, November 30). Statistical Bulletin. Available online: https://www.emcdda.europa.eu/data/stats2022_en.
5. European Monitoring Centre for Drugs and Drug Addiction (2021). Relazione Europea Sulla Droga 2021: Tendenze e Sviluppi, Publications Office.