Iron-Catalyzed Sulfonylmethylation of Imidazo[1,2-α]pyridines with N,N-Dimethylacetamide and Sodium Sulfinates-Reference-Cited by-同舟云学术

Iron-Catalyzed Sulfonylmethylation of Imidazo[1,2-α]pyridines with N,N-Dimethylacetamide and Sodium Sulfinates

Published:2024-07-05 Issue:13 Volume:29 Page:3196
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Sun Shengnan¹,Ye Hexia¹,Liu Haibo¹,Li Junchen¹,Bi Xiaojing¹

Affiliation:

1. State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China

Abstract

Functionalized imidazo[1,2-α]pyridines are important scaffolds in pharmaceuticals. Herein, we present an efficient 3-sulfonylmethylation protocol for imidazo[1,2-α]pyridines by sodium sulfinates in DMA and H2O (2:1) via an FeCl3-catalyzed three-component coupling reaction. Various sulfonylmethyl imidazo[1,2-α]pyridines were thus afforded in high yields with excellent functional group tolerance. A plausible oxidation-addition mechanism was proposed.

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/13/3196/pdf

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