Author:
Wang Zhanyong,Yang Ting,Liu Dongfang,Chen Rongxiang,Wang Nan,Liu Hong,Li Jiarong,Wang Kaikai,Liu Hongxin
Abstract
An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecular to intermolecular domino Michael–aldol–lactonization leading to differential product formation was achieved by different NHCs catalysis.
Funder
National Natural Science Foundation of China
the Program for Youth Backbone Teacher Training in University of Henan Province
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science