Affiliation:
1. Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1 Col Centro, Xochitepec 62790, Morelos, Mexico
2. Plant Innovation Lab, Tecnologico de Monterrey, School of Engineering and Sciences, Centro de Bioingeniería, Av. Epigmenio González No. 500, San Pablo 76130, Queretaro, Mexico
Abstract
The negative impact on worldwide social well-being by the increasing rate of psychiatric diseases has led to a continuous new drug search. Even though the current therapeutic options exert their activity on multiple neurological targets, these have various adverse effects, causing treatment abandonment. Recent research has shown that Coriandrum sativum offers a rich source of metabolites, mainly terpenes and flavonoids, as useful agents against central nervous system disorders, with remarkable in vitro and in vivo activities on models related to these pathologies. Furthermore, studies have revealed that some compounds exhibit a chemical interaction with γ-aminobutyric acid, 5-hydroxytryptamine, and N-methyl-D-aspartate receptors, which are key components in the pathophysiology associated with psychiatric and neurological diseases. The current clinical evaluations of standardized extracts of C. sativum are scarce; however, one or more of its compounds represents an area of opportunity to test the efficacy of the plant as an anxiolytic, antidepressant, antiepileptic, or sleep enhancer. For this, the aim of the review was based on the pharmacological activities offered by the compounds identified and isolated from coriander and the processes involved in achieving their effect. In addition, lines of technological research, like molecular docking and nanoparticles, are proposed for the future development of phytomedicines, based on the bioactive molecules of C. sativum, for the treatment of psychiatric and neurological disorders addressed in the present study.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference157 articles.
1. World Health Organization (2021, June 30). Mental Disorders, Available online: https://www.who.int/news-room/fact-sheets/detail/mental-disorders.
2. World Health Organization (2013). Mental Health Action Plan 2013–2020.
3. Coriander (Coriandrum sativum L.) and its bioactive constituents;Laribi;Fitoterapia,2015
4. Instituto Nacional Indigenista (1994). Atlas de las Plantas de la Medicina Tradicional Mexicana Tomo I, Instituto Nacional Indigenista.
5. Effects of coriandrum sativum syrup on migraine: A randomized, triple-blind, placebo-controlled trial;Kasmaei;Iran. Red Crescent Med. J.,2016