Investigation on Metabolites in Structure and Biosynthesis from the Deep-Sea Sediment-Derived Actinomycete Janibacter sp. SCSIO 52865
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Published:2023-02-24
Issue:5
Volume:28
Page:2133
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Ding Wenping1ORCID, Li Yanqun1, Tian Xinpeng1ORCID, Xiao Zhihui1, Li Ru1, Zhang Si12, Yin Hao123
Affiliation:
1. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 2. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China 3. Sanya Institute of Ocean Eco-Environmental Engineering, Sanya 572000, China
Abstract
For exploring structurally diverse metabolites and uniquely metabolic mechanisms, we systematically investigated the chemical constituents and putative biosynthesis of Janibacter sp. SCSIO 52865 derived from the deep-sea sediment based on the OSMAC strategy, molecular networking tool, in combination with bioinformatic analysis. As a result, one new diketopiperazine (1), along with seven known cyclodipeptides (2–8), trans-cinnamic acid (9), N-phenethylacetamide (10) and five fatty acids (11–15), was isolated from the ethyl acetate extract of SCSIO 52865. Their structures were elucidated by a combination of comprehensive spectroscopic analyses, Marfey’s method and GC-MS analysis. Furthermore, the analysis of molecular networking revealed the presence of cyclodipeptides, and compound 1 was produced only under mBHI fermentation condition. Moreover, bioinformatic analysis suggested that compound 1 was closely related to four genes, namely jatA–D, encoding core non-ribosomal peptide synthetase and acetyltransferase.
Funder
Key-Area Research and Development Program of Guangdong Province National Natural Science Foundation of China the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory Hainan Provincial Natural Science Foundation of China
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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