Abstract
This study processes a facile and green approach for the Markovnikov-selective hydroamination of styrene with naphthylamine through irradiation with UV LED light (365 nm) via an electron donor–acceptor complexation between naphthylamines and oxygen in situ. This protocol showcases the synthetic potential for aerobic C–N bond formation without using a metal catalyst and photosensitizer. Three naphthylamines were examined and afforded desired C–N bond formation product in moderate yield.
Funder
JSPS KAKENHI
Grant-in-Aid for Scientific Research (C) and Transformative Research Areas
Digitalization-driven Transformative Organic Synthesis
Fund for the Promotion of Joint International Research (Fostering Joint International Research
Ministry of Education, Culture, Sports, Science, and Technology
the Japan Society for the Promotion of Science
JST CREST
Hoansha Foundation
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science