Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates-Reference-Cited by-同舟云学术

Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates

Published:2024-05-21 Issue:11 Volume:29 Page:2432
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Pohl Jean-Marie¹,Stöhr Fabian¹,Kramer Tim¹,Becker Jonathan²,Göttlich Richard¹^ORCID

Affiliation:

1. Institute for Organic Chemistry, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany

2. Institute for Inorganic and Analytical Chemistry, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany

Abstract

A microwave-assisted synthesis of dialkyl and cyclic H-phosphonates via bis(2,2,2 trifluoroethyl) phosphonate (BTFEP) is described. This method enables the synthesis of various cyclic H-phosphonates and hetero-substituted dialkyl H-phosphonates by simple alcoholysis under non-inert and additive-free conditions. Short reaction times and the requirement for only stoichiometric amounts of alcohol render this method attractive for synthetic applications.

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/11/2432/pdf

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