Affiliation:
1. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China
Abstract
Myeloid-derived suppressor cells (MDSCs) are recognized as major immune suppressor cells in the tumor microenvironment that may inhibit immune checkpoint blockade (ICB) therapy. Here, we developed a Stattic-loaded mesoporous silica nanoparticle (PEG-MSN-Stattic) delivery system to tumor sites to reduce the number of MDSCs in tumors. This approach is able to significantly deplete intratumoral MSDCs and thereby increase the infiltration of T lymphocytes in tumors to enhance ICB therapy. Our approach may provide a drug delivery strategy for regulating the tumor microenvironment and enhancing cancer immunotherapy efficacy.
Funder
Suzhou Key Laboratory of Nanotechnology and Biomedicine
Collaborative Innovation Center of Suzhou Nano Science & Technology
111 Project
Joint International Research Laboratory of Carbon-Based Functional Materials and Devices