Inositols in PCOS

Author:

Kamenov ZdravkoORCID,Gateva Antoaneta

Abstract

(1) Background: Myoinositol (MI) and D-chiro-inositol (DCI) are involved in a number of biochemical pathways within oocytes having a role in oocyte maturation, fertilization, implantation, and post-implantation development. Both inositols have a role in insulin signaling and hormonal synthesis in the ovaries. (2) Methods: Literature search (with key words: inositols, myo-inositol, d-chiro-inositol, PCOS) was done in PubMed until Sept. 2020 and 197 articles were identified, of which 47 were of clinical trials (35 randomized controlled trials). (3) Results: Many studies have demonstrated that in patients with polycystic ovarian syndrome (PCOS) MI treatment improved ovarian function and fertility, decreased the severity of hyperandrogenism including acne and hirsutism, positively affected metabolic aspects, and modulated various hormonal parameters deeply involved in the reproductive axis function and ovulation. Thus treating with MI has become a novel method to ameliorate PCOS symptoms, improve spontaneous ovulation, or induce ovulation. The current review is focused on the effects of MI and DCI alone or in combination with other agents on the pathological features of PCOS with focus on insulin resistance and adverse metabolic outcomes. (4) Conclusions: The available clinical data suggest that MI, DCI, and their combination in physiological ratio 40:1 with or without other compound could be beneficial for improving metabolic, hormonal, and reproductive aspects of PCOS.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Cited by 60 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. PCOS and common androgen abnormalities in adolescents;NASPAG Essentials of Pediatric & Adolescent Gynecology;2025

2. INOSITOL NO TRATAMENTO DA SÍNDROME DOS OVÁRIOS POLICÍSTICOS: AVALIAÇÃO DA EFICÁCIA;RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218;2024-09-05

3. Best Practices for Identifying and Supporting Patients who Present with PCOS;Nursing Clinics of North America;2024-09

4. The effect of myo‐inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD;Food Science & Nutrition;2024-07-16

5. The Three Lichens: A Generalist Approach to Vulvar Skin Conditions;Canadian Women's Health Today;2024-06-25

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