Abstract
[2+2+2] Cycloaddition reaction is a captivating process that assembles six-membered rings from three unsaturations with complete atom economy. Of the multiple transition metals that can be used to catalyze this reaction, rhodium offers many advantages. These include high activity and versatility, but especially the ability to easily tune the reactivity and selectivity by the modification of the ligands around the metal. In this personal account, we summarize our endeavours in the development of efficient and sustainable [2+2+2] cycloaddition reactions to prepare products of interest, develop conditions in which the catalyst can be recovered and reused, and understand the mechanistic details that govern the selectivity of the processes.
Funder
Generalitat de Catalunya
Ministerio de Ciencia e Innovación in Spain
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Cited by
9 articles.
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