11B NMR of the Morphological Evolution of Traditional Chinese Medicine Borax
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Published:2024-01-03
Issue:1
Volume:29
Page:251
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Li Qiulin1ORCID,
Yang Yawen1,
Wang Qingfeng1,
Han Xiang1,
Zhu Junfeng2ORCID,
Zhang Nan1,
Wang Qiuhong3,
Li Kanshe1,
Gong Pin2,
Chen Fuxin1ORCID
Affiliation:
1. Department of Chemistry and Chemical Engineering, Xi’an University of Science & Technology, Xi’an 710054, China
2. School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China
3. Department of Safety Science and Engineering, Xi’an University of Science & Technology, Xi’an 710054, China
Abstract
This article applies nuclear magnetic resonance technology to the study of boron-containing traditional Chinese medicine, in order to explore the morphological evolution of boron elements in traditional Chinese medicine. Borax is a traditional Chinese medicine with anti-corrosion, anti-inflammatory, antibacterial, and anticonvulsant effects. It is made by boiling, removing stones, and drying borax minerals like borate salts. This article introduces an 11B nuclear magnetic resonance method for identifying and characterizing boron-containing compounds in TCM. We applied this technology to borax aqueous solutions in different chemical environments and found that with boron mixed in the form of SP2 hybridization in equilateral triangles and SP3 hybridization in equilateral tetrahedra, the pH changes in alkaline environments significantly affected the ratio of the two. At the same time, it was found that in addition to the raw material peak, boron signals of other boron-containing compounds were also detected in 20 commercially available boron-containing TCM preparations. These new boron-containing compounds may be true pharmaceutical active ingredients, and adding them directly to the formula can improve quality and safety. This article describes the detection of 11B NMR in boron-containing traditional Chinese medicine preparations. It is simple, non-destructive, and can provide chemical fingerprint studies for boron-containing traditional Chinese medicine.
Funder
National Natural Science Fundamental Project
Shaanxi Natural Science Foundation
China Postdoctoral Science Foundation
Scientific Research Program Funded by Shaanxi Provincial Education Department
Xi’an Science and Technology Plan Project
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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