Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes-Reference-Cited by-同舟云学术

Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes

Published:2024-03-06 Issue:5 Volume:29 Page:1186
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

El Mahdaoui Amal¹^ORCID,Radi Smaail¹^ORCID,Draoui Youssef¹^ORCID,El Massaoudi Mohamed¹,Ouahhoud Sabir²³,Asehraou Abdeslam²^ORCID,Bentouhami Nour Eddine²^ORCID,Saalaoui Ennouamane²^ORCID,Benabbes Redouane²^ORCID,Robeyns Koen⁴^ORCID,Garcia Yann⁴^ORCID

Affiliation:

1. LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco

2. Laboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco

3. Faculty of Medicine and Pharmacy, University Sultan Moulay Slimane, Beni Mellal 23000, Morocco

4. Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium

Abstract

In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L1) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L2), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L1)2](ClO4)2 (C1) and a dinuclear complex [Cd2(L2)2]Cl4 (C2). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L1 and L2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C1 and C2.

Funder

Fonds de la Recherche Scientifique—FNRS

CNRST

COST action

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/5/1186/pdf

Reference63 articles.

1. Future Antibacterial Strategies: From Basic Concepts to Clinical Challenges;Cattoir;J. Infect. Dis.,2019

2. World Health Organization (2021). 2021 Antibacterial Agents in Clinical and Preclinical Development: An Overview and Analysis, World Health Organization.

3. Metal Complexes as a Promising Source for New Antibiotics;Frei;Chem. Sci.,2020

4. Coordination Chemistry of Pyrazole-Derived Ligands;Swiatoslaw;Chem. Rev.,1972

5. Ebenezer, O., Shapi, M., and Tuszynski, J.A. (2022). A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives. Biomedicines, 10.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis and biological activity evaluation of eco‐friendly rosin‐based fungicides for sustainable crop protection;Pest Management Science;2024-07-19