Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds-Reference-Cited by-同舟云学术

Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds

Published:2024-04-03 Issue:7 Volume:29 Page:1608
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Kabieva Saule¹,Zhumanazarova Gaziza¹,Zhaslan Rymgul¹,Zhumabayeva Gulistan²,Ukhov Arthur³,Fedorishin Dmitry³^ORCID,Gubankov Alexander³,Tarikhov Farkhad³^ORCID,Yerkhan Ordabay²,Irina Kurzina³^ORCID,Yerkassov Rakhmetulla²,Bakibaev Abdigali³^ORCID

Affiliation:

1. Department of Chemical Technology and Ecology, Karaganda Industrial University, Temirtau 101400, Kazakhstan

2. Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, St. Satbaeva 2, Almaty District, Astana 010000, Kazakhstan

3. Chemical Faculty, National Research Tomsk State University, Arkady Ivanov St. 49, Tomsk 634028, Russia

Abstract

This study aimed to create new composite materials based on diatomite—a non-organic porous compound—through its surface modification with bioactive organic compounds, both synthetic and natural. Chloramphenicol, tetrahydroxymethylglycoluril and betulin were used as modifying substances. Composite materials were obtained by covering the diatomite surface with bioactive substance compounds as a solution and material dispersion in it. The materials were characterized by IR spectroscopy, SEM and X-ray photoelectron spectroscopy. For the biocomposites, the hemolytic effect, plasma proteins’ adsorption on the surface and the antibacterial activity of the obtained materials were studied. Results show that the obtained materials are promising for medicine and agriculture.

Funder

Russian Science Foundation

Tomsk State University Development Program (Priority-2030), Russia

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/7/1608/pdf

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