Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System-Reference-Cited by-同舟云学术

Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System

Published:2023-03-03 Issue:5 Volume:28 Page:2355
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Al-Zaydi Khadijah M.¹,Saleh Tamer S.¹²^ORCID,Alqahtani Norah F.¹,Bagazi Meaad S.¹

Affiliation:

1. Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia

2. Green Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt

Abstract

We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitrile to form the desired bis azines and bis azoles. A combination of elemental analyses and spectral data was used to confirm the structures of the products. Compared with conventional heating, the high-pressure Q-Tube method promotes reactions in a short period of time and provides high yields.

Funder

the Deputyship for Research & Innovation, Minis-try of Education in Saudi Arabia for funding this research work

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/5/2355/pdf

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