Abstract
Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of A. pseudoglehnii (APE) against influenza virus infection. Two chlorophyll derivatives, ethyl pheophorbides a and b, isolated as active components of APE, exerted virucidal effects with no evident cytotoxicity. These compounds were effective only under conditions of direct incubation with the virus, and exerted no effects on the influenza A virus (IAV) surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Interestingly, virucidal activities of ethyl pheophorbides a and b were observed against enveloped but not non-enveloped viruses, suggesting that these compounds act by affecting the integrity of the viral membrane and reducing infectivity.
Funder
Korea Institute of Science and Technology
Gachon University
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference40 articles.
1. Rajasekaran, D., Palombo, E.A., Yeo, T.C., Ley, D.L.S., Tu, C.L., Malherbe, F., and Grollo, L. (2013). Identification of traditional medicinal plant extracts with novel anti-influenza activity. PLoS ONE, 8.
2. Influenza virus and SARS-CoV-2: Pathogenesis and host responses in the respiratory tract;Flerlage;Nat. Rev. Microbiol.,2021
3. The evolution of seasonal influenza viruses;Petrova;Nat. Rev. Microbiol.,2018
4. The persistent legacy of the 1918 influenza virus;Morens;N. Engl. J. Med.,2009
5. Influenza virus: Immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines;Cox;Scand. J. Immunol.,2004
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