Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review-Reference-Cited by-同舟云学术

Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review

Published:2023-03-17 Issue:6 Volume:28 Page:2722
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Mushtaq Aqsa¹,Zahoor Ameer Fawad¹^ORCID,Bilal Muhammad²^ORCID,Hussain Syed Makhdoom³^ORCID,Irfan Muhammad⁴,Akhtar Rabia¹⁵,Irfan Ali¹^ORCID,Kotwica-Mojzych Katarzyna⁶,Mojzych Mariusz⁷^ORCID

Affiliation:

1. Medicinal Chemistry Research Lab, Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan

2. College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China

3. Department of Zoology, Government College University Faisalabad, Faisalabad 38000, Pakistan

4. Department of Pharmaceutics, Government College University Faisalabad, Faisalabad 38000, Pakistan

5. Department of Chemistry, Superior University, Faisalabad 38000, Pakistan

6. Laboratory of Experimental Cytology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland

7. Department of Chemistry, Siedlce University of Natural Sciences and Humanities, 3-Go Maja 54, 08-110 Siedlce, Poland

Abstract

Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand. Sharpless introduced this methodology after considering the importance of enantioselectivity in the total synthesis of medicinally important compounds. Vicinal diols, produced as a result of this reaction, act as intermediates in the synthesis of different naturally occurring compounds. Hence, Sharpless asymmetric dihydroxylation plays an important role in synthetic organic chemistry due to its undeniable contribution to the synthesis of biologically active organic compounds. This review emphasizes the significance of Sharpless asymmetric dihydroxylation in the total synthesis of various natural products, published since 2020.

Funder

Medical University of Lublin

Siedlce University of Natural Sciences and Humanities

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/6/2722/pdf

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