Advancements in the Biotransformation and Biosynthesis of the Primary Active Flavonoids Derived from Epimedium
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Published:2023-10-19
Issue:20
Volume:28
Page:7173
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Zhang Xiaoling123, Tang Bingling12, Wen Sijie12, Wang Yitong12, Pan Chengxue1, Qu Lingbo4, Yin Yulong5, Wei Yongjun2ORCID
Affiliation:
1. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China 2. Laboratory of Synthetic Biology, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China 3. Key Laboratory of Food Safety Quick Testing and Smart Supervision Technology for State Market Regulation, Zhengzhou 450003, China 4. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China 5. Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410081, China
Abstract
Epimedium is a classical Chinese herbal medicine, which has been used extensively to treat various diseases, such as sexual dysfunction, osteoporosis, cancer, rheumatoid arthritis, and brain diseases. Flavonoids, such as icariin, baohuoside I, icaritin, and epimedin C, are the main active ingredients with diverse pharmacological activities. Currently, most Epimedium flavonoids are extracted from Epimedium plants, but this method cannot meet the increasing market demand. Biotransformation strategies promised huge potential for increasing the contents of high-value Epimedium flavonoids, which would promote the full use of the Epimedium herb. Complete biosynthesis of major Epimedium flavonoids by microbial cell factories would enable industrial-scale production of Epimedium flavonoids. This review summarizes the structures, pharmacological activities, and biosynthesis pathways in the Epimedium plant, as well as the extraction methods of major Epimedium flavonoids, and advancements in the biotransformation and complete microbial synthesis of Epimedium flavonoids, which would provide valuable insights for future studies on Epimedium herb usage and the production of Epimedium flavonoids.
Funder
National Natural Science Foundation of China Clinical Laboratories, Shenyou Bio
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference147 articles.
1. Taxonomic study of Epimedium L.: Status, issues and prospect;Xu;Guihaia,2020 2. The genus Epimedium: An ethnopharmacological and phytochemical review;Ma;J. Ethnopharmacol.,2011 3. Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective: A narrative review;Niu;Transl. Androl. Urol.,2022 4. Seyedi, Z., Amiri, M.S., Mohammadzadeh, V., Hashemzadeh, A., Haddad-Mashadrizeh, A., Mashreghi, M., Qayoomian, M., Hashemzadeh, M.R., Simal-Gandara, J., and Taghavizadeh Yazdi, M.E. (2023). Icariin: A promising natural product in biomedicine and tissue engineering. J. Funct. Biomater., 14. 5. Chinese Pharmacopoeia Commission (2020). Pharmacopoeia of the People’s Republic of China, China Medical Science Press.
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2 articles.
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