Serinol-Based Versatile Disulfide-Reducing Reagent-Reference-Cited by-同舟云学术

Serinol-Based Versatile Disulfide-Reducing Reagent

Published:2023-07-18 Issue:14 Volume:28 Page:5489
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Kushwaha Babita¹,Mthembu Sinenhlanhla¹²^ORCID,Sharma Anamika¹²³^ORCID,Albericio Fernando²⁴^ORCID,de la Torre Beatriz¹^ORCID

Affiliation:

1. KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa

2. Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000, South Africa

3. Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

4. CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain

Abstract

Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a reducing agent was evaluated in both liquid and solid phases. The reducing capacity of this agent was comparable to that of DTT.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/14/5489/pdf

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