Study of Salidroside and Its Inflammation Targeting Emulsion Gel for Wound Repair

Author:

Wang Xiaojie12,Yang Jun2,Luo Shuai2,Zhang Hucheng2,Liu Bo3ORCID,Pan Zhiquan1

Affiliation:

1. School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China

2. School of Biological Engineering, Beijing Polytechnic, Beijing 100176, China

3. Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

Abstract

Salidroside has been widely used in anti-tumor, cardiovascular, and cerebrovascular protection. However, there are few reports of its use for wound repair. Herein, salidroside inflammation-targeted emulsion gel and non-targeted emulsion gel were developed for wound repair. The inflammation-targeted emulsion gels showed an overall trend of better transdermal penetration and lower potential than non-targeted emulsion gels (−58.7 mV and −1.6 mV, respectively). The apparent improvement of the trauma surface was significant in each administration group. There was a significant difference in the rate of wound healing of the rats between each administration group and the model group at days 7 and 14. Pathological tissue sections showed that inflammatory cells in the epidermis, dermis, and basal layer were significantly reduced, and the granulation tissue was proliferated in the inflammation-targeted emulsion gel group and the non-targeted emulsion gel group. Regarding the expressions of EGF and bFGF, the expressions of bFGF and EGF in the tissues of the inflammation-targeted group at days 7, 14, or 21 were significantly higher than that of the non-targeted emulsion gel group and the model group, both of which were statistically significant compared with the model group (p < 0.05). These results demonstrated that salidroside has the potential as an alternative drug for wound repair.

Funder

Study on Dracorhodin Perchlorate Targeting Nano Preparation and Its Mechanism of Sciatica

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Reference38 articles.

1. Research progress on the pharmacological effects and mechanism of tibetan medicine Rhodiola rosea;Wang;China Pharm.,2019

2. Research status, questions and strategies of rare medicinal plant rhodiola L;Wang;J. Nat. Resour.,2007

3. Enhancing the chemotherapy effect of apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis;Zhang;Drug Deliv.,2020

4. Salidroside improves angiogenesis-osteogenesis coupling by regulating the HIF-1α/VEGF signalling pathway in the bone environment;Guo;Eur. J. Pharmacol.,2020

5. Salidroside downregulates microRNA-133a and inhibits endothelial cell apoptosis induced by oxidized low-density lipoprotein;Zhang;Int. J. Mol. Med.,2020

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