Phytosynthesis of Silver Nanoparticle (AgNPs) Using Aqueous Leaf Extract of Knoxia Sumatrensis (Retz.) DC. and Their Multi-Potent Biological Activity: An Eco-Friendly Approach
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Published:2022-11-14
Issue:22
Volume:27
Page:7854
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Loganathan Settu, Selvam Kuppusamy, Shivakumar Muthugounder Subaramanian, Senthil-Nathan SengottayanORCID, Vasantha-Srinivasan PrabhakaranORCID, Gnana Prakash Dhakshinamoorthy, Karthi Sengodan, Al-Misned Fahad, Mahboob ShahidORCID, Abdel-Megeed AhmedORCID, Ghaith Aml, Krutmuang PatcharinORCID
Abstract
Green synthesis of silver nanoparticles (AgNPs) has gained greater interest among chemists and researchers in this current scenario. The present research investigates the larvicidal and anti-proliferation activity of AgNPs derived from Knoxiasumatrensis aqueous leaf extract (K. sumatrensis-ALE) as a potential capping and reducing candidate. The synthesized AgNPs were characterized through-UV-spectra absorption peak at 425 nm. The XRD and FT-IR studied displayed the crystalline nature and presence of functional groups in prepared samples. FE-SEM showed the hexagonal shape of NPs with the size of 7.73 to 32.84 nm. The synthesized AgNPs displayed superior antioxidant and anti-proliferative activity (IC50 53.29 µg/mL) of breast cancer cell line (MCF-7). Additionally, larvicidal activity against mosquito vector Culex quinquefasciatus larvae delivered (LC50-0.40, mg/L, and LC90-15.83) significant mortality rate post treatment with synthesized AgNPs. Overall, the present research illustrates that the synthesized AgNPs have high biological potential and present a perfect contender in the pharmacological and mosquitocidal arena.
Funder
Chiang Mai University King Saud University, Riyadh, Saudi Arabia department of science and technology (DST-FIST), India
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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