Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa
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Published:2023-08-10
Issue:16
Volume:28
Page:6004
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Gębalski Jakub1, Małkowska Milena1, Graczyk Filip1, Słomka Artur2ORCID, Piskorska Elżbieta3, Gawenda-Kempczyńska Dorota1ORCID, Kondrzycka-Dąda Aneta4, Bogucka-Kocka Anna5ORCID, Strzemski Maciej6ORCID, Sowa Ireneusz6ORCID, Wójciak Magdalena6ORCID, Grzyb Sebastian7, Krolik Krystian1, Ptaszyńska Aneta A.8ORCID, Załuski Daniel1
Affiliation:
1. Department of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland 2. Department of Pathophysiology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland 3. Department of Pathobiochemistry and Clinical Chemistry, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland 4. University of Social Sciences, 11 Łucka Str., 00-842 Warsaw, Poland 5. Department of Biology and Genetics, Medical University of Lublin, 20-093 Lublin, Poland 6. Department of Analytical Chemistry, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland 7. College of Engineering and Health in Warsaw, Bitwy Warszawskiej 1920 r. 18 Str., 02-366 Warsaw, Poland 8. Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 Str., 20-033 Lublin, Poland
Abstract
Despite the fact that there are many studies related to the adaptogenic and pro-healthy activities of plant-based compounds, there are some adaptogenic plants whose activities are not fully known, especially those coming from the wild regions of Asia, Africa, and South America. The aim of these studies was to examine the contents of non-nutritional compounds, such as polyphenols, flavonoids, and phenolic acids in ten adaptogenic species (Astragalus membranaceus (AM), Uncaria rhynchophylla (UR), Polygonum multiflorum (PM), Angelica sinensis (AS), Andrographis paniculatea (AP), Tinospora cordifolia (TC), Uncaria tomentosa (UT), Pfaffia paniculate (PP), Sutherlandia frutescens (SF), and Rhaponticum carthamoides (RC)). Considering biological activity, their antioxidant (DPPH, ABTS, FRAP, and ferrous-ion-chelating ability assays), anti-acetylcholinesterase, anti-hyaluronidase, and anti-tyrosinase activities were evaluated. The richest in polyphenols, flavonoids, and phenolic acids was UR (327.78 mg GAE/g, 230.13 mg QE/g, and 81.03 mg CA/g, respectively). The highest inhibitions of acetylcholinesterase, hyaluronidase, and tyrosinase were observed for TC, UR, and PM, respectively. In the case of antioxidant properties, extract from PM appeared to most strongly reduce DPPH, extract from UR inhibited ABTS, and extract from SF showed the best chelating properties. It should be noted that a particularly interesting plant was Ulcaria rhynchophylla. The results mean that there were compounds in UR with broad biological activities, and this species should be explored in more detail. Additionally, our results justify the traditional use of these species in the nutripharmacological or ethnopharmacological care systems of different regions.
Funder
IDUB, Nicolaus Copernicus University—Grants4NCUStudents Minigrants for NCU students
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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