Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran Arabinoxylan Compound

Author:

Schupfer Emily1ORCID,Ooi Soo Liang1ORCID,Jeffries Thomas C.2ORCID,Wang Shaoyu34ORCID,Micalos Peter S.5ORCID,Pak Sok Cheon1ORCID

Affiliation:

1. School of Dentistry and Medical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia

2. School of Science, Western Sydney University, Penrith, NSW 2751, Australia

3. School of Dentistry and Medical Sciences, Charles Sturt University, Orange, NSW 2800, Australia

4. Ageing Well Research Group, Charles Sturt University, Orange, NSW 2800, Australia

5. School of Dentistry and Medical Sciences, Charles Sturt University, Port Macquarie, NSW 2444, Australia

Abstract

This study investigated the effects of a modified rice bran arabinoxylan compound (RBAC) as a dietary supplement on the gut microbiota of healthy adults. Ten volunteers supplemented their diet with 1 g of RBAC for six weeks and 3 g of RBAC for another six weeks, with a three-week washout period. Faecal samples were collected every 3 weeks over 21 weeks. Microbiota from faecal samples were profiled using 16S rRNA sequencing. Assessment of alpha and beta microbiota diversity was performed using the QIIME2 platform. The results revealed that alpha and beta diversity were not associated with the experimental phase, interventional period, RBAC dosage, or time. However, the statistical significance of the participant was detected in alpha (p < 0.002) and beta (weighted unifrac, p = 0.001) diversity. Explanatory factors, including diet and lifestyle, were significantly associated with alpha (p < 0.05) and beta (p < 0.01) diversity. The individual beta diversity of six participants significantly changed (p < 0.05) during the interventional period. Seven participants showed statistically significant taxonomic changes (ANCOM W ≥ 5). These results classified four participants as responders to RBAC supplementation, with a further two participants as likely responders. In conclusion, the gut microbiome is highly individualised and modulated by RBAC as a dietary supplement, dependent on lifestyle and dietary intake.

Funder

BioMedica Nutraceuticals Pty Ltd

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Reference73 articles.

1. Role of the gut microbiota in nutrition and health;Valdes;BMJ,2018

2. Introduction to host microbiome symbiosis in health and disease;Malard;Mucosal Immunol.,2021

3. Microbiome survey of the inflamed and noninflamed gut at different compartments within the gastrointestinal tract of inflammatory bowel disease patients;Forbes;Inflamm. Bowel Dis.,2016

4. Arabinoxylans, gut microbiota and immunity;Mendis;Carbohydr. Polym.,2016

5. Manipulating the gut microbiota to maintain health and treat disease;Scott;Microb. Ecol. Health Dis.,2015

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3