Abstract
Learning and memory are essential to organism survival and are conserved across various species, especially vertebrates. Cognitive studies involving learning and memory require using appropriate model organisms to translate relevant findings to humans. Zebrafish are becoming increasingly popular as one of the animal models for neurodegenerative diseases due to their low maintenance cost, prolific nature and amenability to genetic manipulation. More importantly, zebrafish exhibit a repertoire of neurobehaviors comparable to humans. In this review, we discuss the forms of learning and memory abilities in zebrafish and the tests used to evaluate the neurobehaviors in this species. In addition, the pharmacological studies that used zebrafish as models to screen for the effects of neuroprotective and neurotoxic compounds on cognitive performance will be summarized here. Lastly, we discuss the challenges and perspectives in establishing zebrafish as a robust model for cognitive research involving learning and memory. Zebrafish are becoming an indispensable model in learning and memory research for screening neuroprotective agents against cognitive impairment.
Funder
Universiti Kebangsaan Malaysia
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference129 articles.
1. Gerlai, R. Chapter 12—Associative and Nonassociative Learning in Adult Zebrafish. Behavioral and Neural Genetics of Zebrafish, 2020.
2. Zebrafish as an animal model for biomedical research;Choi;Exp. Mol. Med.,2021
3. Zebrafish disease models in drug discovery: From preclinical modelling to clinical trials;Patton;Nat. Rev. Drug Discov.,2021
4. Construction of an Affordable Open-Design Recirculating Zebrafish Housing System;Teoh;J. Am. Assoc. Lab. Anim. Sci.,2020
5. Modeling Parkinson’s Disease in Zebrafish;Najib;CNS Neurol. Disord. Drug Targets,2020
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