Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications

Author:

Keszei Soma J.12ORCID,Váradi Márk1ORCID,Skoda-Földes Rita1ORCID

Affiliation:

1. Research Group of Organic Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, 8200 Veszprém, Hungary

2. Université de Rouen Normandie, 1 Rue Tesniere, 76821 Mont-Saint-Aignan Cedex, France

Abstract

Ureido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor sites to supplement those in the urea core, and they can also bind metals and can be modified by pH, redox reactions or irradiation. In the present review, the main structural features of these derivatives are discussed, including the effect of tautomerization and conformational isomerism on self-assembly and complex formation. Some examples of their use as building blocks in different molecular architectures and supramolecular polymers, with special emphasis on biomedical applications, are presented. The role of the heterocyclic functionality in catalytic and sensory applications is also outlined.

Funder

Thematic Excellence Programme by the National Research; Development and Innovation Fund of Hungary

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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