Author:
Yang Zaibo,Li Pei,Gan Xiuhai
Abstract
In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus (TMV). In particular, compounds 6a, 6c and 6q exhibited the best curative activity, protection activity, and inactivation activity against TMV, respectively, which were superior to those of Ningnanmycin. This study demonstrated that this series of novel pyrazole-hydrazone derivatives containing an isoxazole amide moiety could effectively control TMV.
Funder
National Natural Science Foundation of China
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference37 articles.
1. Plant Virus;Xie,2009
2. Biological activity of ningnanmycin on tobacco mosaic virus;Deng;Chin. J. Appl. Environ. Biol.,2004
3. Design, Synthesis, Antiviral Activity, and SARs of 14-Aminophenanthroindolizidines
4. Environment-Friendly Antiviral Agents for Plants;Song,2010
5. The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives
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