Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine

Author:

Egwu Chinedu O.12ORCID,Aloke Chinyere23ORCID,Onwe Kenneth T.4,Umoke Chukwunalu Igbudu4,Nwafor Joseph4,Eyo Robert A.2,Chukwu Jennifer Adaeze5ORCID,Ufebe Godswill O.2,Ladokun Jennifer6,Audu David Tersoo7,Agwu Anthony O.2,Obasi David Chukwu8,Okoro Chukwuemeka O.8ORCID

Affiliation:

1. Medical Research Council, London School of Hygiene and Tropical Medicine, Banjul 220, The Gambia

2. Medical Biochemistry Department, College of Medicine, Alex-Ekwueme Federal University Ndufu-Alike, P.M.B. 1010, Ikwo 482131, Nigeria

3. Protein Structure-Function and Research Unit, School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Braamfontein, Johannesburg 2050, South Africa

4. Anatomy Department, College of Medicine, Alex-Ekwueme Federal University Ndufu-Alike, P.M.B. 1010, Ikwo 482131, Nigeria

5. World Health Organization, United Nations House Plot 617/618 Central Area District, P.M.B. 2861, Abuja 900211, Nigeria

6. Society for Family Health, 20 Omotayo Ojo Street, Allen, Ikeja 100246, Nigeria

7. UNICEF Sokoto Field Office, 2 Rahamaniyya Street, Off Sama Road, Sokoto 840224, Nigeria

8. Department of Medical Biochemistry, David Umahi Federal University of Health Sciences, Uburu 491105, Nigeria

Abstract

There is a myriad of diseases that plague the world ranging from infectious, cancer and other chronic diseases with varying interventions. However, the dynamism of causative agents of infectious diseases and incessant mutations accompanying other forms of chronic diseases like cancer, have worsened the treatment outcomes. These factors often lead to treatment failure via different drug resistance mechanisms. More so, the cost of developing newer drugs is huge. This underscores the need for a paradigm shift in the drug delivery approach in order to achieve desired treatment outcomes. There is intensified research in nanomedicine, which has shown promises in improving the therapeutic outcome of drugs at preclinical stages with increased efficacy and reduced toxicity. Regardless of the huge benefits of nanotechnology in drug delivery, challenges such as regulatory approval, scalability, cost implication and potential toxicity must be addressed via streamlining of regulatory hurdles and increased research funding. In conclusion, the idea of nanotechnology in drug delivery holds immense promise for optimizing therapeutic outcomes. This work presents opportunities to revolutionize treatment strategies, providing expert opinions on translating the huge amount of research in nanomedicine into clinical benefits for patients with resistant infections and cancer.

Publisher

MDPI AG

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