Microfluidic Preparation of pH-Responsive Microsphere Fibers and Their Controlled Drug Release Properties
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Published:2023-12-28
Issue:1
Volume:29
Page:193
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Wang Ning12, Wei Yixuan3, Hu Yanrong4, Sun Xiaoting12, Wang Xiaohong1
Affiliation:
1. Center of 3D Printing & Organ Manufacturing, School of Intelligent Medicine, China Medical University, Shenyang 110122, China 2. Department of Chemistry, School of Forensic Medicine, China Medical University, Shenyang 110122, China 3. Teaching Center for Basic Medical Experiment, China Medical University, Shenyang 110122, China 4. Department of Biological Physics, School of Intelligent Medicine, China Medical University, Shenyang 110122, China
Abstract
In this study, a capillary microfluidic device was constructed, and sodium alginate solution and a pH-sensitive hydrophobic polymer (p(BMA-co-DAMA-co-MMA)) solution were introduced into the device for the preparation of hydrogel fibers loaded with polymer microspheres. The structure of the microsphere fiber, including the size and spacing of the microspheres, could be controlled by flow rate, and the microspheres were able to degrade and release cargo responding to acidic pH conditions. By modification with carboxymethylcellulose (CMC), alginate hydrogel exhibited enhanced pH sensitivity (shrunk in acidic while swollen in basic condition). This led to an impact on the diffusion rate of the molecules released from the inner microspheres. The microsphere fiber showed dramatic and negligible degradation and drug release in tumor cell (i.e., A431 and A549 cells) and normal cell environments, respectively. These results indicated that the microsphere fiber prepared in this study showed selective drug release in acidic environments, such as tumor and inflammation sites, which could be applied as a smart surgical dressing with normal tissue protective properties.
Funder
National Natural Science Foundation of China Natural Science Foundation of Liaoning Province in China Foundation of the Education Department of Liaoning Province in China Key Research & Development Project of Liaoning Province China Post-Doctoral Science Foundation
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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