Author:
Ivashchenko Andrey A.,Zagribelnyy Bogdan A.,Ivanenkov Yan A.,Ivashchenko Ilya A.,Karapetian Ruben N.,Kravchenko Dmitry V.,Savchuk Nikolay P.,Yakubova Elena V.,Ivachtchenko Alexandre V.
Abstract
The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Cited by
3 articles.
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