Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents-Reference-Cited by-同舟云学术

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Published:2019-09-21 Issue:19 Volume:24 Page:3433
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Khandazhinskaya Anastasia,Matyugina Elena,Solyev Pavel^ORCID,Wilkinson Maggie,Buckheit Karen,Buckheit Robert,Chernousova Larisa,Smirnova Tatiana,Andreevskaya Sofya,Alzahrani Khalid,Natto Manal,Kochetkov Sergey,de Koning Harry^ORCID,Seley-Radtke Katherine^ORCID

Abstract

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

Funder

Russian Foundation for Basic Research

Government of Saudi Arabia

Taif University

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/24/19/3433/pdf

Reference45 articles.

1. The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold

2. The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

3. Carbocyclic nucleoside analogues: classification, target enzymes, mechanisms of action and synthesis

4. 5′-Nor carbocyclic nucleosides: unusual nonnucleoside inhibitors of HIV-1 reverse transcriptase

5. Structure-activity evaluation of new uracil-based non-nucleoside inhibitors of HIV reverse transcriptase

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