A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88-Reference-Cited by-同舟云学术

A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88

Published:2021-05-14 Issue:10 Volume:26 Page:2909
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Ventura Juan^ORCID,Uriel Clara^ORCID,Gomez Ana M.^ORCID,Avellanal-Zaballa Edurne,Bañuelos Jorge^ORCID,García-Moreno Inmaculada,Lopez Jose Cristobal^ORCID

Abstract

A convergent synthetic route to a tetrasaccharide related to PI-88, which allows the incorporation of a fluorescent BODIPY-label at the reducing-end, has been developed. The strategy, which features the use of 1,2-methyl orthoesters (MeOEs) as glycosyl donors, illustrates the usefulness of suitably-designed BODIPY dyes as glycosyl labels in synthetic strategies towards fluorescently-tagged oligosaccharides.

Funder

Ministerio de Economia y Competitividad, Gobierno de España

Ministerio de Ciencia, Innovación y Universidades

Gobierno Vasco

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/26/10/2909/pdf

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