2-Imidazoline Nitroxide Derivatives of Cymantrene

Author:

Maryunina Kseniya,Letyagin GlebORCID,Romanenko GalinaORCID,Bogomyakov ArtemORCID,Morozov Vitaly,Tumanov Sergey,Veber SergeyORCID,Fedin MatveyORCID,Saverina Evgeniya,Syroeshkin Mikhail,Egorov Mikhail,Ovcharenko Victor

Abstract

The 2-imidazoline nitroxide derivatives of cymantrene—2-(η5-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (NNMn) and 2-(η5-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-1-oxyl (INMn) were synthesized. It was shown that NNMn and INMn exhibit a sufficiently high kinetic stability both in solids and in solutions under normal conditions. Their structural characteristics, magnetic properties and electrochemical behavior are close to Re(I) analogs. This opens the prospect of using paramagnetic cymantrenes as prototypes in the design of Re(I) half-sandwiched derivatives for theranostics, where therapy is combined with diagnostics by magnetic resonance imaging due to the contrast properties of nitroxide radicals.

Funder

Russian Foundation for Basic Research

Russian Science Foundation

Ministry of Education and Science of the Russian Federation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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