Occurrence of Luteolin in the Greek Flora, Isolation of Luteolin and Its Action for the Treatment of Periodontal Diseases
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Published:2023-11-22
Issue:23
Volume:28
Page:7720
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Arampatzis Athanasios S.12ORCID, Pampori Aspasia12, Droutsa Eleftheria12ORCID, Laskari Maria3, Karakostas Panagiotis4, Tsalikis Lazaros4ORCID, Barmpalexis Panagiotis25ORCID, Dordas Christos3ORCID, Assimopoulou Andreana N.12ORCID
Affiliation:
1. School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece 2. Natural Products Research Center of Excellence (NatPro-AUTH), Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, 57001 Thessaloniki, Greece 3. School of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece 4. School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece 5. Laboratory of Pharmaceutical Technology, Division of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Abstract
Higher plants possess the ability to synthesize a great number of compounds with many different functions, known as secondary metabolites. Polyphenols, a class of flavonoids, are secondary metabolites that play a crucial role in plant adaptation to both biotic and abiotic environments, including UV radiation, high light intensity, low/high temperatures, and attacks from pathogens, among others. One of the compounds that has received great attention over the last few years is luteolin. The objective of the current paper is to review the extraction and detection methods of luteolin in plants of the Greek flora, as well as their luteolin content. Furthermore, plant species, crop management and environmental factors can affect luteolin content and/or its derivatives. Luteolin exhibits various biological activities, such as cytotoxic, anti-inflammatory, antioxidant and antibacterial ones. As a result, luteolin has been employed as a bioactive molecule in numerous applications within the food industry and the biomedical field. Among the different available options for managing periodontitis, dental care products containing herbal compounds have been in the spotlight owing to the beneficial pharmacological properties of the bioactive ingredients. In this context, luteolin’s anti-inflammatory activity has been harnessed to combat periodontal disease and promote the restoration of damaged bone tissue.
Funder
European Regional Development Fund of the European Union and Greek national funds
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference102 articles.
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