Affiliation:
1. Department of Oceanography, Kunsan National University, Jeonbuk 54150, Republic of Korea
2. Department of Plant & Biomaterials Science, Gyeongsang National University, Jinju 52725, Republic of Korea
3. Department of Marine Biotechnology, Kunsan National University, Jeonbuk 54150, Republic of Korea
Abstract
There were five sesquiterpene lactones, belonging to the eudesmanolide class, isolated from the halophyte Sonchus brachyotus DC. The structures of the compounds were determined using spectroscopic methods, including 1D and 2D NMR spectra, MS data, and optical rotation values. Compounds 4 and 5 were characterized by the position of p-hydroxyphenylacetyl group in the sugar moiety. In the evaluation of anti-inflammatory effects on LPS-activated RAW264.7 macrophages, compound 1, 5α,6βH-eudesma-3,11(13)-dien-12,6α-olide, potently suppressed the expression of iNOS and COS-2, as well as the production of TNF-α, IL-6, and IL-10. Treatment of 1 regulates the Nrf2/HO-1 pathway.
Funder
the Korea Institute of Marine Science & Technology Promotion
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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