Enantiocomplementary Bioreduction of 1-(Arylsulfanyl)propan-2-ones-Reference-Cited by-同舟云学术

Enantiocomplementary Bioreduction of 1-(Arylsulfanyl)propan-2-ones

Published:2024-08-15 Issue:16 Volume:29 Page:3858
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Sándor Emese¹,Csuka Pál¹^ORCID,Poppe László¹^ORCID,Nagy József¹

Affiliation:

1. Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary

Abstract

This study explored the enantiocomplementary bioreduction of substituted 1-(arylsulfanyl)propan-2-ones in batch mode using four wild-type yeast strains and two different recombinant alcohol dehydrogenases from Lactobacillus kefir and Rhodococcus aetherivorans. The selected yeast strains and recombinant alcohol dehydrogenases as whole-cell biocatalysts resulted in the corresponding 1-(arylsulfanyl)propan-2-ols with moderate to excellent conversions (60–99%) and high selectivities (ee > 95%). The best bioreductions—in terms of conversion (>90%) and enantiomeric excess (>99% ee)—at preparative scale resulted in the expected chiral alcohols with similar conversion and selectivity to the screening reactions.

Funder

Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund

European Union

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/16/3858/pdf

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