Abstract
The Nef reaction (nitro to carbonyl group conversion) and related Meyer reaction are among the key transformations of aliphatic nitro compounds. The interrupted versions of these reactions in which the normal pathway is redirected to a different end product by an external nucleophile are much less common, albeit these processes substantially increase the synthetic potential of nitro compounds. In this review, examples of interrupted Nef and Meyer reactions are summarized, and the prospects of this methodology in diversity-oriented organic synthesis are analyzed. The bibliography contains 90 references.
Funder
Russian Science Foundation
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference90 articles.
1. Ueber die nitroverbindungen der fettreihe. Sechste mittheilung;Meyer;Chem. Ber.,1873
2. Nitrating action of nitric acid on saturated hydrocarbons;Konovalov;J. Russ. Phys. Chem. Soc.,1893
3. Ueber die constitution der salze der nitroparaffine;Nef;Liebigs Ann. Chem.,1894
4. Transformation of nitroparaffins;Bamberger;Chem. Ber.,1902
5. Structure of isonitro compounds;Nametkin;J. Russ. Phys. Chem. Soc.,1914
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