Biological Activities of Organic Extracts of the Genus Aristolochia: A Review from 2005 to 2021

Author:

Lerma-Herrera Martín A.ORCID,Beiza-Granados Lidia,Ochoa-Zarzosa AlejandraORCID,López-Meza Joel E.ORCID,Navarro-Santos Pedro,Herrera-Bucio RafaelORCID,Aviña-Verduzco JuditORCID,García-Gutiérrez Hugo A.ORCID

Abstract

Different ethnomedicinal studies have investigated the relationship between various phytochemicals as well as organic extracts and their bioactive aspects. Studies on biological effects are attributed to secondary metabolites such as alkaloids, phenolic compounds, and terpenes. Since there have been no reviews in the literature on the traditional, phytochemical, and ethnomedicinal uses of the genus Aristolochia so far, this article systematically reviews 141 published studies that analyze the associations between secondary metabolites present in organic extracts and their beneficial effects. Most studies found associations between individual secondary metabolites and beneficial effects such as anticancer activity, antibacterial, antioxidant activity, snake anti-venom and anti-inflammatory activity. The aim of this review was to analyze studies carried out in the period 2005–2021 to update the existing knowledge on different species of the genus Aristolochia for ethnomedicinal uses, as well as pharmacological aspects and therapeutic uses.

Funder

Consejo Nacional de Ciencia y Tecnología

CIC-Universidad Michoacana de San Nicolás de Hidalgo

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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