Abstract
This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Cited by
25 articles.
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e
][1,2,4]triazine and pyrazolo[4,3-
e
]tetrazolo[1,5-
b
][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures;Journal of Enzyme Inhibition and Medicinal Chemistry;2024-05-03
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