Abstract
The blood–brain barrier (BBB) serves as a protective barrier for the central nervous system (CNS) against drugs that enter the bloodstream. The BBB is a key clinical barrier in the treatment of CNS illnesses because it restricts drug entry into the brain. To bypass this barrier and release relevant drugs into the brain matrix, nanotechnology-based delivery systems have been developed. Given the unstable nature of NPs, an appropriate amount of a biocompatible polymer coating on NPs is thought to have a key role in reducing cellular cytotoxicity while also boosting stability. Human serum albumin (HSA), poly (lactic-co-glycolic acid) (PLGA), Polylactide (PLA), poly (alkyl cyanoacrylate) (PACA), gelatin, and chitosan are only a few of the significant polymers mentioned. In this review article, we categorized polymer-coated nanoparticles from basic to complex drug delivery systems and discussed their application as novel drug carriers to the brain.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference192 articles.
1. Sikdar, S., and Guha, S. (2020). Recent Trends in Image and Signal Processing in Computer Vision, Springer.
2. Oxidative stress in neurodegenerative diseases: From molecular mechanisms to clinical applications;Liu;Oxid. Med. Cell. Longev.,2017
3. Ageing, neurodegeneration and brain rejuvenation;Nature,2016
4. Metals and neurodegenerative diseases. A systematic review;Cicero;Environ. Res.,2017
5. Sabir, F., Ain, Q.U., Rahdar, A., Yang, Z., Barani, M., Bilal, M., and Bhalla, N. (2022). Synthesis and Applications of Nanoparticles, Springer.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献