Abstract
A series of novel thiochromanone derivatives containing a sulfonyl hydrazone moiety were designed and synthesized. Their structures were determined by 1H-NMR, 13C-NMR, and HRMS. Bioassay results showed that most of the target compounds revealed moderate to good antibacterial activities against Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzicolaby, and Xanthomonas axonopodis pv. citri. Compound 4i had the best inhibitory activity against Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzicolaby, and Xanthomonas axonopodis pv. citri, with the EC50 values of 8.67, 12.65, and 10.62 μg/mL, which were superior to those of Bismerthiazol and Thiodiazole-copper. Meanwhile, bioassay results showed that all of the target compounds proved to have lower antifungal activities against Sclerotinia sclerotiorum, Fusarium oxysporum, Gibberella zeae, Rhizoctonia solani, Verticillium dahlia, and Botrytis cinerea than those of Carbendazim.
Funder
National Key R&D Program of China
Science and Technology Foundation of Guizhou Province
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference29 articles.
1. An overview of fungal and bacterial biopesticides to control plant pathogens/diseases;Bhattacharjee;Afr. J. Microbiol. Res.,2014
2. Agronanotechnology for plant fungal disease management: A review;Patel;Int. J. Curr. Microbiol. App. Sci.,2014
3. Chromanols, chromanones, and chromones
4. Synthesis and antifungal activity of 3-substituted-benzylidene-6,7-methylenedioxy-4-chromanone;Wang;Chin. J. Pest. Sci.,2013
5. Recent advances in the research of chromone and thiochromone derivatives as antifungal agents;Yu;Chin. J. Antibiot.,2011
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