Arthproliferins A–D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221-Reference-Cited by-同舟云学术

Arthproliferins A–D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221

Published:2023-10-24 Issue:21 Volume:28 Page:7246
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Yang Bin¹^ORCID,Li Cuitian²,Chen Ying¹,He Yanchun¹,She Jianglian¹,Zhou Xuefeng¹^ORCID,Tao Huangming³^ORCID,Peng Bo⁴

Affiliation:

1. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

2. Marine Environmental Engineering Center, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510515, China

3. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China

4. Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, China

Abstract

Four new sesterterpenes, arthproliferins A–D (1–4), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of the isolated compounds were evaluated for their cytotoxicity in vitro. The results revealed that terpestacin (6) exhibited significant activity with an IC50 value of 20.3 μM, and compounds 2 and 5 were found to show weak inhibitory effects against U87MG-derived GSCs.

Funder

Marine Economy Development Project of Guangdong Province

National Natural Science Foundation of China

Guangdong Basic and Applied Basic Research Foundation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/21/7246/pdf

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