Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1

Author:

de Alencar Daniel Machado,Gonçalves JulianaORCID,Vieira AndreiaORCID,Cerqueira Sofia A.,Sebastião CruzORCID,Leitão Maria Inês P. S.ORCID,Francescato GiuliaORCID,Antenori Paola,Soares Helena,Petronilho Ana

Abstract

We report herein a set of 3′-azido-3′-deoxythymidine (AZT) derivatives based on triazoles and triazolium salts for HIV-1 infection. The compounds were synthesized via click chemistry with Cu(I) and Ru(II) catalysts. Triazolium salts were synthesized by reaction with methyl iodide or methyl triflate in good yields. The antiviral activity of the compounds was tested using two methodologies: In method one the activity was measured on infected cells; in method two a pre-exposure prophylaxis experimental model was employed. For method one the activity of the compounds was moderate, and in general the triazolium salts showed a decreased activity in relation to their triazole precursors. With method two the antiviral activity was higher. All compounds were able to decrease the infection, with two compounds able to clear almost all the infection, while a lower antiviral activity was noted for the triazolium salts. These results suggest that these drugs could play an important role in the development of pre-exposure prophylaxis therapies.

Funder

Fundação para a Ciência e Tecnologia

Gilead Génese

Universidade Nova de Lisboa

European Society of Clinical Microbiology and Infectious Diseases

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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