Author:
Fan Daoqing,Ou Jiale,Chen Ling,Zhang Lichao,Zheng Zhiren,Yu Haizhu,Meng Xiangming,Zhu Manzhou
Abstract
Recent decades have witnessed the rapid progress of nanozymes and their high promising applications in catalysis and bioclinics. However, the comprehensive synthetic procedures and harsh synthetic conditions represent significant challenges for nanozymes. In this study, monodisperse, ultrasmall gold clusters with peroxidase-like activity were prepared via a simple and robust one-pot method. The reaction of clusters with H2O2 and 3,3′,5,5′-tetramethylbenzidine (TMB) followed the Michaelis-Menton kinetics. In addition, in vitro experiments showed that the prepared clusters had good biocompatibility and cell imaging ability, indicating their future potential as multi-functional materials.
Funder
National Natural Science Foundation of China
University Synergy Innovation Program of Anhui Province
National Science Foundation of Anhui Province
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science