Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance-Reference-Cited by-同舟云学术

Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance

Published:2023-07-07 Issue:13 Volume:28 Page:5278
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Tseme Wandji Nadine¹²³,Bitchagno Gabin Thierry M.³⁴^ORCID,Mawabo Kamga Isabelle⁵,Tchamgoue Joseph¹²^ORCID,Nkenfou Celine Nguefeu⁵⁶^ORCID,Lenta Bruno Ndjakou¹,Sewald Norbert³^ORCID,Kouam Simeon Fogue¹^ORCID

Affiliation:

1. Department of Chemistry, Higher Teacher Training College, University of Yaounde I, Yaounde P.O. Box 47, Cameroon

2. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde P.O. Box 812, Cameroon

3. Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany

4. Department of Chemistry, University of Dschang, Dschang P.O. Box 67, Cameroon

5. Department of Biology, Higher Teacher Training College, University of Yaounde I, Yaounde P.O. Box 47, Cameroon

6. Molecular Biology Center, Yaounde P.O. Box 14495, Cameroon

Abstract

Four polyoxygenated stigmastanes (1–4) alongside known analogues (7–8) and flavonoids (5–6) were isolated from a dichloromethane/methanol (1:1, v/v) extract of the whole plant of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Their structures were determined by means of spectroscopic and spectrometric analysis. The relative stereochemistry of the new compounds was established and confirmed via biosynthesis evidence and cyclization of 1 under acidic conditions. A plausible biosynthetic pathway to the new compounds and the chemophenetic significance of the isolated constituents were also discussed. The crude extract, fractions, and compounds (1–3) were assessed for their antibacterial activity against five highly prevalent bacterial strains. The fractions and compounds showed low to moderate activity with minimal inhibitory concentrations (MICs) > 125 µg/mL.

Funder

German Academic Exchange Service

Alexander von Humboldt Foundation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/13/5278/pdf

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