Synthesis, Characterization, X-ray Molecular Structure, Antioxidant, Antifungal, and Allelopathic Activity of a New Isonicotinate-Derived meso-Tetraarylporphyrin-Reference-Cited by-同舟云学术

Synthesis, Characterization, X-ray Molecular Structure, Antioxidant, Antifungal, and Allelopathic Activity of a New Isonicotinate-Derived meso-Tetraarylporphyrin

Published:2024-07-03 Issue:13 Volume:29 Page:3163
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Dardouri Nour Elhouda¹^ORCID,Hrichi Soukaina¹²,Torres Pol³,Chaâbane-Banaoues Raja²^ORCID,Sorrenti Alessandro³,Roisnel Thierry⁴^ORCID,Turowska-Tyrk Ilona⁵^ORCID,Babba Hamouda²,Crusats Joaquim³⁶^ORCID,Moyano Albert³^ORCID,Nasri Habib¹

Affiliation:

1. Laboratory of Physical Chemistry of Materials (LR01ES19), Faculty of Science of Monastir, University of Monastir, Avenue de l’Environment, Monastir 5019, Tunisia

2. Laboratory of Medical and Molecular Parasitology-Mycology (LP3M), Faculty of Pharmacy, University of Monastir, LR12ES08, Monastir 5000, Tunisia

3. Section of Organic Chemistry, Department of Inorganic and Organic Chemistry, Faculty of Chemistry, University of Barcelona, C. de Martí i Franquès 1-11, 08028 Barcelona, Spain

4. Institute of Chemical Sciences of Rennes, UMR 6226, University of Rennes 1, Beaulieu Campus, 35042 Rennes, France

5. Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

6. Institute of Cosmos Science, University of Barcelona, C. de Martí i Franquès 1-11, 08028 Barcelona, Spain

Abstract

The present article describes the synthesis of an isonicotinate-derived meso-arylporphyrin, that has been fully characterized by spectroscopic methods (including fluorescence spectroscopy), as well as elemental analysis and HR-MS. The structure of an n-hexane monosolvate has been determined by single-crystal X-ray diffraction analysis. The radical scavenging activity of this new porphyrin against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical has been measured. Its antifungal activity against three yeast strains (C. albicans ATCC 90028, C. glabrata ATCC 64677, and C. tropicalis ATCC 64677) has been tested using the disk diffusion and microdilution methods. Whereas the measured antioxidant activity was low, the porphyrin showed moderate but encouraging antifungal activity. Finally, a study of its effect on the germination of lentil seeds revealed interesting allelopathic properties.

Funder

Ministerio de Ciencia, Innovación y Universidades (MICIU), Agencia Estatal de Investigación

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/13/3163/pdf

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