Affiliation:
1. Key Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, China
2. Collaborative Innovation Center for Farmland Weeds Control Techniques and Application of Hunan Province, Hunan University of Humanities Science and Technology, Loudi 417000, China
Abstract
Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of high-dose DM on growth and development, and the mechanism of toxicity remains unclear. Using the Caenorhabditis elegans model, we found that high-dose DM caused a delay in nematode development. Our results showed that high-dose DM reduced the activation of the endoplasmic reticulum unfolded protein response (UPRER). Further studies revealed that high-dose DM-induced developmental toxicity and reduced capacity for UPRER activation were associated with the IRE-1/XBP-1 pathway. Our results provide new evidence for the developmental toxicity of DM and new insights into the mechanism of DM toxicity.
Funder
Project of the Education Department in Hunan Province
Hunan Provincial Postgraduate Research Innovation Project
Natural Science Foundation of Hunan Province
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science