Affiliation:
1. West China School of Pharmacy, Sichuan University, Chengdu 610041, China
2. School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Abstract
Seven new phenylhexanoids, (S)-(+)-3,4-dihydroxy-11-methoxyphenylhex-9-one (1), (E) 3,4-dihydroxy-phenylhex-10-en-9-one (2), (E)-4-hydroxyphenylhex-10-en-9-one (3), (R)-(−)-3,4,11-trihydroxyphenylhex-9-one 11-O-β-d-glucopyranoside (4), (R)-(−)-4,11-dihydroxyphenylhex-9-one 11-O-β-d-glucopyranoside (5), phenylhex-4,9,11-triol 11-O-β-d-glucopyranoside (6), and 9-O-acetyl-phenylhex-4,9,11-triol 11-O-β-d-glucopyranoside (7), were isolated and identified from Tibetan medicine Saxifraga umbellulata var. pectinate. The antioxidant activities of these compounds were evaluated using the DPPH and ABTS radical scavenging experiments. In the ABTS experiment, compounds 1 (IC50 13.99 ± 2.53 μM) and 2 (IC50 13.11 ± 0.94 μM) exhibited significantly better antioxidant activity than L-ascorbic acid (IC50 23.51 ± 0.44 μM).
Funder
National Natural Science Foundation of China
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference21 articles.
1. (1992). The Editorial Committee of Flora Reipublicae Popularis Sinicae (Zhongguo Zhiwu Zhi), Science Press.
2. The resources and usage status of the commonly used Tibetan Medicinal Crop Dida;Zhong;Chin. World Sci. Tech.-Mod. TCM Mater. Med.,2010
3. Improvement of Quality Standard for Tibetan Medicine “Songdi”;Luo;Chin. World Sci. Tech.-Mod. TCM Mater. Med.,2022
4. Wu, R. (2014). Studies on the Chemical Constituents and Antibacterial Activity of Saxifrage umbellulata. [Master’s Thesis, Lanzhou University of Technology].
5. The effect of flavonoids from Tibetan medicine ‘Songti’ on the oxidative damage of L02 hepatocytes;Fei;Tradit. Chin. Drug Res. Pharmacol.,2021