Abstract
The design of novel metal complexes with N-heterocyclic carbene (NHC) ligands that display biological activity is an active research field in organometallic chemistry. One of the possible approaches consists of the use of NHC ligands functionalized with a carbohydrate moiety. Two novel Au(I)–Au(I) dinuclear complexes were synthesized; they present a neutral structure with one bridging diNHC ligand, having one or both heterocyclic rings decorated with a carbohydrate functionality. With the symmetric diNHC ligand, the dicationic dinuclear complex bearing two bridging diNHC ligands was also synthesized. The study was completed by analyzing the antiproliferative properties of these complexes, which were compared to the activity displayed by similar mononuclear Au(I) complexes and by the analogous bimetallic Au(I)–Au(I) complex not functionalized with carbohydrates.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference53 articles.
1. Structure, Recognition, and Processing of Cisplatin−DNA Adducts
2. Cisplatin: The first metal based anticancer drug
3. N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools;Diez-Gonzalez,2017
4. An overview of N-heterocyclic carbenes
5. The Organometallic Chemistry of N-heterocyclic Carbenes;Huynh,2017
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