Photodynamic Inactivation of Microorganisms Using Semisynthetic Chlorophyll a Derivatives as Photosensitizers

Author:

Uliana Marciana PierinaORCID,da Cruz Rodrigues Andréia,Ono Bruno Andrade,Pratavieira SebastiãoORCID,de Oliveira Kleber ThiagoORCID,Kurachi Cristina

Abstract

In this study, we describe the semisynthesis of cost-effective photosensitizers (PSs) derived from chlorophyll a containing different substituents and using previously described methods from the literature. We compared their structures when used in photodynamic inactivation (PDI) against Staphylococcus aureus, Escherichia coli, and Candida albicans under different conditions. The PSs containing carboxylic acids and butyl groups were highly effective against S. aureus and C. albicans following our PDI protocol. Overall, our results indicate that these nature-inspired PSs are a promising alternative to selectively inactivate microorganisms using PDI.

Funder

São Paulo Research Foundation

CNPQ

PRPPG UNILA

Coordenação de Aperfeicoamento de Pessoal de Nível Superior

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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