Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides-Reference-Cited by-同舟云学术

Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides

Published:2023-07-14 Issue:14 Volume:28 Page:5412
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Mourtas Spyridon¹^ORCID,Athanasopoulos Vasileios¹,Gatos Dimitrios¹,Barlos Kleomenis²

Affiliation:

1. Department of Chemistry, University of Patras, 26510 Rio Patras, Greece

2. CBL-Patras, Patras Industrial Area, Block 1, 25018 Patras, Greece

Abstract

2-benzothiazoles and 2-(aminophenyl)benzothiazoles represent biologically interesting heterocycles with high pharmacological activity. The combination of these heterocycles with amino acids and peptides is of special interest, as such structures combine the advantages of amino acids and peptides with the advantages of the 2-benzothiazolyl and 2-(aminophenyl)benzothiazolyl pharmacophore group. In this work, we developed an easy and efficient method for the solid-phase synthesis of 2-benzothiazolyl (BTH) and 2-(aminophenyl)benzothiazolyl (AP-BTH) C-terminal modified amino acids and peptides with high chiral purity.

Funder

University of Patras

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/14/5412/pdf

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