Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines-Reference-Cited by-同舟云学术

Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines

Published:2021-07-14 Issue:14 Volume:26 Page:4274
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Aksenov Alexander V.^ORCID,Grishin Igor Yu.^ORCID,Aksenov Nicolai A.,Malyuga Vladimir V.,Aksenov Dmitrii A.,Nobi Mezvah A.,Rubin Michael

Abstract

Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.

Funder

Russian Foundation for Basic Research

Ministry of Education and Science of the Russian Federation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/26/14/4274/pdf

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